Human Prion Diseases

دانلود کتاب  (handbook) Human Prion Diseases

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems.

Table of contents :

Front Matter ….Pages i-xv
Kuru: Introduction to Prion Diseases (Paweł P. Liberski, Agata Gajos)….Pages 1-31
Anthropological Methods Used in Kuru Research (Shirley Lindenbaum)….Pages 33-48
Nonhuman Primates in Research on Transmissible Spongiform Encephalopathies (David M. Asher, Pedro Piccardo, Luisa Gregori)….Pages 49-63
Clinical Features and Diagnosis of Human Prion Diseases (Richard Knight)….Pages 65-78
Neuropathology, Immunohistochemistry, and Biochemistry in Human Prion Diseases (Diane L. Ritchie, James W. Ironside)….Pages 79-97
Subcellular and Molecular Changes Associated with Abnormal PrP Accumulation in Brain and Viscera of Classical and Atypical Prion Diseases (Martin Jeffrey, Gillian McGovern)….Pages 99-121
Electron Microscopy of Prion Diseases (Paweł P. Liberski)….Pages 123-143
Cell Death and Autophagy in Prion Diseases (Pawel P. Liberski)….Pages 145-158
Methods for Isolation of Spiroplasma sp. from Prion-Positive Eye Tissues of Sheep Affected with Terminal Scrapie (Frank O. Bastian)….Pages 159-172
Detection and Diagnosis of Prion Diseases Using RT-QuIC: An Update (Byron Caughey, Christina D. Orru, Bradley R. Groveman, Matilde Bongianni, Andrew G. Hughson, Lynne D. Raymond et al.)….Pages 173-181
Analysis of Charge Isoforms of the Scrapie Prion Protein Using Two-Dimensional Electrophoresis (Elizaveta Katorcha, Ilia V. Baskakov)….Pages 183-196
Exosomes in Prion Diseases (Alexander Hartmann, Hermann Altmeppen, Susanne Krasemann, Markus Glatzel)….Pages 197-207
Synthetic Mammalian Prions (Fabio Moda, Edoardo Bistaffa, Joanna Narkiewicz, Giulia Salzano, Giuseppe Legname)….Pages 209-228
Biomarkers in Cerebrospinal Fluid (Joanna Gawinecka, Matthias Schmitz, Inga Zerr)….Pages 229-252
The Use of Transgenic and Knockout Mice in Prion Research (Abigail B. Diack, Jean C. Manson)….Pages 253-267
Transgenic Mouse Models of Prion Diseases (Julie Moreno, Glenn C. Telling)….Pages 269-301
Back Matter ….Pages 303-304